The Toffees first game of the group stage is away at Atalanta and in summer signing Wayne Rooney, they have a player who knows how to win the competition.
Rooney was part of the Manchester United squad that lifted the trophy against Ajax last summer and Everton manager Ronald Koeman will be hoping that the forward can repeat that feat for his side this term.
The Merseysiders flew to Italy on Wednesday morning and Rooney was among the travelling party seen heading through Liverpool’s John Lennon airport.
It’s a big week for Rooney who will then follow Thursday’s clash with his first return to Old Trafford on Sunday in the Premier League since re-joining Everton.
However, first and foremost he and his team-mates will be looking to right the wrongs of the weekend’s 3-0 home defeat by Tottenham against Atalanta.
The Toffees were unbeaten in their first six games in domestic and European competition but have now followed defeat at Chelsea with that hammering by Spurs.
And speaking after that loss, Rooney’s team-mate Michael Keane is desperate for Everton to show what they can do against their Serie A counterparts.
‘Yes, thankfully we have Europe. We need to get this game behind us and the best way to do it is to play another one,’ said the England centre back.
‘I can’t wait to play Thursday personally and get another chance to put things right. We’re into the group stage, which is big for us. But we’ve also got to put Tottenham behind us quickly and move on the next few days.
‘I’m sure the lads will be raring to go to try and get the win.’