Jurgen Klopp’s side have won all three Group D games without conceding a goal, and victory in one of their remaining fixtures should be enough to take them through to the knockout stages.
Portugal international Jota showed why he was given a start ahead of Roberto Firmino by scoring for a fourth consecutive game, dinking in a delightful opener before doubling the lead with a thumping strike at the near post.
He completed his triple in the second period, collecting Sadio Mane’s pass before going round goalkeeper Marco Sportiello and slotting into an open net.
In between Jota’s third, the Reds netted two quick-fire goals at the start of the second half as Mohamed Salah took full advantage of an exposed backline to run clear and curl home and Mane clipped in the fourth.
The Serie A side had sniffs of goal, but Duvan Zapata’s strike from the angle hit the post, while two efforts from Luis Muriel were comfortable for goalkeeper Alisson to deal with.
In the group’s other game, Dutch side Ajax picked up their first of the campaign by beating Midtjylland 2-1, as the Danish team remain bottom of the group and without a point.
Alongside Mane and Salah, Firmino has been an automatic choice in Liverpool’s front three during the club’s period of success in recent years.
But the Brazil international has been off-colour this season, scoring just once in 10 games, and so Jota was given an opportunity in Bergamo which he grabbed in sublime fashion.
Some eyebrows were raised at the £41m fee paid to sign the player from Wolves, but the 23-year-old looks every bit a Liverpool player as he took his tally to seven goals in 10 games this term.
Buzzing around in the final third, he latched on to Trent Alexander-Arnold’s defence-splitting pass before warding off the attentions of defender Jose Luis Palomino and chipping in a cool finish.
He took his second with aplomb, bringing down Joe Gomez’s raking pass and firing in at the near post, before rolling in the third on 54 minutes to take home the match ball.